Initially, the Profiles tab is empty. In order to create a performance profile, you need to click the "record" button in the toolbar ribbon at the bottom of the pane; it's the fourth icon, the black circle.
The profile information is displayed in five columns. The first column, "Self", is the amount of time that was spent executing code within the method. The second column, "Total" is the cumulative amount of time spent executing that method and all methods called by the method.
The total time also depends on how many times the method was called. The "Average" column represents the average execution time for all the times this method was invoked.
Beneath the performance metrics, additional buttons are added to the toolbar ribbon. The first is a drop-down that lets you switch from "Tree" to "Heavy" view. The heavy view lets you see which functions are taking up the most execution time and the calling paths to those functions.
The second icon, the percent symbol, lets you switch from viewing the performance metrics as a relative percentage to seeing them in terms of their actual execution time.
The "eye" icon lets you "zoom" in so you only see the metrics for a single function. The "X" icon lets you exclude the performance metrics for a specific function from the profile.