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Bioprocess Engineering, Third Edition, is a comprehensive update of the world's leading introductory textbook on biochemical and bioprocess engineering. Drs. Michael L. Shuler, Fikret Kargi, and Matthew DeLisa review the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve consistent control over biological activity. The authors introduce techniques with broad application to the production of pharmaceuticals, biologics, and commodities; to medical applications such as tissue engineering and gene therapy; and for solving critical environmental problems. Through up-to-date examples and homework problems, they introduce powerful advances that are transforming the field, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA.
Part I: The Basics of Biology: An Engineer’s Perspective
Chapter 1: What Is a Bioprocess Engineer?
Chapter 2: An Overview of Biological Basics
Chapter 3: Enzymes
Chapter 4: How Cells Work
Chapter 5: Major Metabolic Pathways
Chapter 6: How Cells Grow
Chapter 7: Stoichiometry of Microbial Growth and Product Formation
Chapter 8: How Cellular Information Is Altered
Part II: Engineering Principles for Bioprocesses
Chapter 9: Operating Considerations for Bioreactors for Suspension and Immobilized Cultures
Chapter 10: Selection, Scale-Up, Operation, and Control of Bioreactors
Chapter 11: Recovery and Purification of Products
Chapter 12: Bioprocess Considerations in Using Animal Cell Cultures
Chapter 13: Bioprocess Considerations in Using Plant Cell Cultures
Chapter 14: Utilizing Genetically Engineered Organisms
Chapter 15: Medical Applications of Bioprocess Engineering
Chapter 16: Multiple Species in Culture
Appendix A: Traditional Industrial Bioprocesses