I've worked in a few shops that were all one vendor. Sun hardware, Oracle software, that kind of thing. And I think many of us have worked in all Microsoft shops.
But as a DBA, possibly more than any other position I've held, I've always dealt with multiple vendors, and even multiple versions of those vendors.
That can be kind of a pain. Do you become an expert on each platform, or buy some kind of third party product to manage all of them? I've done both, and each has advantages and disadvantages. I've actually come down on the side of learning both sets of tools, and then using scripting for my cross platform stuff. While I like Microsoft's new PowerShell environment, I still use Perl for the cross-platform stuff. More on Perl here.
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